Also called the de Cabral Scientific Reserve; this second lagoon area is located at the eastern end of the Neiba Valley, in the dry southwestern part of the country. It's the second-largest lagoon in the Dominican Republic with the largest spot of fresh water in inland Dominican.

The lagoon is reachable by good paved road from Santo Domingo. Here you'll find the largest population of endemic freshwater turtles called sliders. Many kinds of shallow-water wading birds also make the lagoon their home.